I’m constantly revising the wireframes portion of my workflow, and for last few projects, I alternated between InDesign and Fireworks. The hardest part of using either has been designing for different browser dimensions seeing as both programs are fairly inflexible in how much they allow the user to change the document size for different pages. Adobe caught on to ID’s rise in popularity for wireframing, and thus: alternate layouts to the rescue in CS6. I rushed to download the trial, but was met by an installer for the downloader for the actual InDesign CS6 installer… except the downlader installer didn’t work due a possibly Adobe-Air-related error. Typical Adobe fare.
Newest revision to process: start wireframing in-browser. Try to cut Adobe out completely.